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¡۹35%,6813-38-3 Formula,2092312-45-1 web,130309-37-4 Technical Information,69570-83-8 manufacturer,42058-59-3 Order Online,174565-63-0 Purity ¡۹41%,159858-21-6 In Stock,63878-73-9 Data Sheet,30363-03-2 manufacturer,362670-06-2 site,106719-44-2 Description,771-97-1 Documentation,381247-99-0 Data Sheet,65868-63-5 Documentation,63639-61-2 manufacturer,885952-18-1 web,88824-09-3 chemscene,117519-07-0 Documentation,365996-06-1 Description,25339-99-5 Data Sheet,352535-84-3 manufacturer,124668-49-1 HPLC,16265-11-5 manufacturer,187344-92-9 chemscene,5900-59-4 Description,1185295-39-9 site,1343056-10-9 HPLC,14997-58-1 Building Blocks,28562-61-0 chemscene,2150-93-8 In Stock,1296209-28-3 NMR,165727-45-7 Technical Information,1220028-20-5 Technical Information,16097-60-2 supplier,84153-82-2 supplier,87014-28-6 supplier,1201643-59-5 Formula,123926-62-5 MS,32993-05-8 Data Sheet,860296-12-4 HPLC,400899-84-5 Formula,89976-27-2 chemscene,599183-33-2 site,7781-10-4 manufacturer,447-53-0 Technical Information,1735-89-3 web,1447963-75-8 custom synthesis,4815-29-6 chemscene,3788-56-5 chemscene,916792-15-9 manufacturer,56131-46-5 Documentation,882679-40-5 Description,6602-33-1 manufacturer,1000414-38-9 Formula,847818-55-7 site,29176-55-4 Formula,131747-63-2 Technical Information,194995-47-6 Technical Information,1214337-57-1 Description,221295-04-1 chemscene,762229-49-2 Formula,870238-67-8 Data Sheet,112970-44-2 web,163451-81-8 Technical Information,256411-39-9 Formula,1002334-12-4 Building Blocks,943152-94-1 Documentation,25021-08-3 NMR,1240948-77-9 HPLC,714951-87-8 supplier,3539-97-7 Documentation,3190-71-4 Technical Information,219503-74-9 custom synthesis,169243-86-1 web,51985-95-6 web,25181-50-4 Description,261715-71-3 chemscene,445-13-6 chemscene,37688-96-3 chemscene,934996-78-8 Description,597551-56-9 Technical Information,66131-68-8 supplier,113206-03-4 site,820236-81-5 HPLC,1260665-60-8 Building Blocks,2380-36-1 Technical Information,937599-94-5 Formula,19008-71-0 manufacturer,1010120-55-4 supplier,88048-43-5 Description,1352144-78-5 web,6665-97-0 web,192214-06-5 Formula,70416-53-4 chemscene,99455-15-9 Purity ¡۱030%,60633-26-3 Documentation,2103-49-3 web,84964-24-9 Documentation,1567892-21-0 Documentation,790184-33-7 chemscene,1030012-30-6 web,25566-00-1 Order Online,6947-94-0 MS,91760-66-6 Building Blocks,696-40-2 Description,1410002-81-1 custom synthesis,345954-83-8 supplier,32111-28-7 Documentation,779-27-1 HPLC,4108-90-1 MS,877-90-7 Purity ¡۱046%,95715-87-0 Data Sheet,1210419-26-3 Description,174603-38-4 Technical Information,167479-13-2 Description,55750-48-6 Formula,5154-01-8 Data Sheet,66361-67-9 Technical Information,106984-09-2 web,306960-74-7 Data Sheet,89466-16-0 Documentation,1185297-53-3 web,2199-58-8 Description,1142400-61-0 Formula,62456-34-2 site,5147-80-8 manufacturer,854107-53-2 Documentation,3034-48-8 web,412947-54-7 web,819058-34-9 Description,1049706-73-1 Documentation,697300-73-5 Technical Information,203787-91-1 custom synthesis,337904-92-4 chemscene,2589531-74-6 MS,66207-23-6 Technical Information,501435-91-2 Description collected in the ARISCAT study [14] and previous studies on the incidence of postoperative pulmonary complications [12,13,30]. A two group c2 test with a 0.05 two-sided significance level will have 80 power to detect the difference (in post-operative pulmonary complications) between conventional mechanical ventilation (24 ) and open lung mechanical ventilation (16.5 ) (Odds ratio of 0.626) when the sample size in each group is 450. Interim analysis – one main concern is not to withhold positive effects of the open lung mechanical ventilation strategy to the control group. Therefore, interim analyses are performed after 300 and 600 patients. The first interim analysis is performed when 300 patients have successfully been included and followed-up. If the intervention has a strong trend for improving post-operative pulmonary complications (as defined above) with a p-value < 0.0005 is found at 300 patients or <0.014 at 600 patients,Normally distributed PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/23410069 variables will be expressed by their mean and standard deviation; not normally distributed variables will be expressed by their medians and interquartile ranges; categorical variables will be expressed as n ( ). In test groups of continuous normally distributed variables, Student’s t-test will be used. Likewise if continuous data are not normally distributed the Mann-Whitney U test will be used. Categorical variables will be compared with the Chi-square test or Fisher’s exact tests or when appropriate as relative risks. Where appropriate statistical uncertainty will be expressed by 95 confidence levels. Primary outcome is the total occurrence of pulmonary complications within the first 5 post-operative days, presented as a percentage. The percentage will be analyzed as continuous data. If the data is normally distributed, Student’s t-test will be used or when not normally distributed 4-Bromopicolinaldehyde the Dimethyl 4-iodopyridine-2,6-dicarboxylate Mann-Whitney U test will be used. As this is a randomized controlled trial, we expect that randomization in this large study population will sufficiently balance the baseline characteristics. Baseline balance is tested and imbalance compensated in all preoperative variables and on ARISCAT scores [14] (as mentioned above). However if imbalance occurs, the confounding factor will be corrected using a multiple logistic regression model. For this we will treat the proportion as a binary response (complications occur during day one to day five post-operative). Time to event variables (primary and secondary outcomes) are analyzed using a proportional hazard model adjusted for possible imbalances of patients’ baseline characteristics. Time course variables (e.g. repeated measures of vital parameters, blood values, VAS-scores, actual mobility) are analyzed by a linear mixed model. The linear mixed models procedure expands the GLM so that the data are permitted to exhibit correlated and non-constant variability. The model includes two factors: 1) study group (fixed factor, intervention or control group), each level of the study group factor can have a different linear effect on the PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/16883776 value of the dependent variable; 2) time as a covariate, time is considered to be a random sample from a larger population of values, the effect is not limited to the chosen times.Study Organization The Executive Committee is constituted of the study principal investigator and the principal investigators ofHemmes et al. Trials 2011, 12:111 http://www.trialsjournal.com/content/12/1/Page 7 ofthe investigating centers that.
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Biochemical Assay Reagents